Manuel Modiano Selected Research

4- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- one

1/2018	A Phase 2 Randomized, Double-Blind, Multicenter Trial of Imexon Plus Gemcitabine Versus Gemcitabine Plus Placebo in Patients With Metastatic Chemotherapy-naïve Pancreatic Adenocarcinoma.
5/2007	Phase I trial of imexon in patients with advanced malignancy.

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Manuel Modiano Research Topics

Disease

4	Neoplasms (Cancer) 01/2020 - 09/2003
3	Thrombocytopenia (Thrombopenia) 01/2019 - 09/2004
2	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 12/2002
2	Neutropenia 01/2020 - 09/2006
2	Adenocarcinoma 01/2018 - 09/2006
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 09/2004
1	Anemia 01/2020
1	Circulating Neoplastic Cells 01/2020
1	Fatigue 01/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2019
1	Pancreatic Neoplasms (Pancreatic Cancer) 09/2006
1	Breast Neoplasms (Breast Cancer) 06/2005
1	Vomiting 09/2003
1	Leukopenia 09/2003
1	Nausea 09/2003
1	Asthenia 09/2003
1	Fever (Fevers) 09/2003
1	Mucositis 09/2003
1	Hyperbilirubinemia 09/2003
1	Disease Progression 12/2002

Drug/Important Bio-Agent (IBA)

3	Gemcitabine FDA Link 01/2018 - 09/2004
2	Prostate-Specific Antigen (Semenogelase)IBA 01/2020 - 12/2002
2	4- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- oneIBA 01/2018 - 05/2007
1	ElectrolytesIBA 01/2020
1	abirateroneIBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	enzalutamideIBA 01/2020
1	PSMA ADCIBA 01/2020
1	AntigensIBA 01/2020
1	TKM-080301IBA 01/2019
1	Polo-Like Kinase 1IBA 01/2019
1	Small Interfering RNA (siRNA)IBA 01/2019
1	130-nm albumin-bound paclitaxelIBA 01/2018
1	Carboplatin (JM8)FDA LinkGeneric 01/2018
1	exatecan (DX 8951f)IBA 09/2006
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/2005
1	Fluorouracil (Carac)FDA LinkGeneric 06/2005
1	Docetaxel (Taxotere)FDA Link 06/2005
1	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2005
1	laromustine (VNP40101M)IBA 03/2005
1	Alkylating AgentsIBA 03/2005
1	Cisplatin (Platino)FDA LinkGeneric 09/2004
1	Protein Kinase C-alphaIBA 09/2004
1	ISIS 3521IBA 09/2004
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 09/2003
1	Bicarbonates (Hydrogen Carbonate)IBA 09/2003
1	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 09/2003
1	Mitoxantrone (Novantrone)FDA LinkGeneric 12/2002
1	Hormones (Hormone)IBA 12/2002
1	Prednisone (Sone)FDA LinkGeneric 12/2002

Therapy/Procedure

3	Therapeutics 01/2020 - 12/2002
2	Drug Therapy (Chemotherapy) 01/2018 - 09/2006
1	Castration 01/2020
1	Adjuvant Chemotherapy 06/2005
1	Aftercare (After-Treatment) 09/2003
1	Time-to-Treatment 12/2002